Thoughts and Ideas
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Dr. Kamran Ali

Lung Transplant in India
Kamran Ali

Lung Transplant Surgery in India: A Complete Guide

For those suffering from end-stage lung diseases, a lung transplant is a life-saving surgery and can be a great source of relief. Lung transplant surgery is a complex and life-saving procedure that is used to treat certain types of lung diseases, such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, bronchiectasis and cystic fibrosis. Although still in its infancy, Lung transplant surgery in India has made tremendous progress in recent years, with many highly qualified and experienced doctors taking up this challenge. This guide will provide a comprehensive overview of the process of a lung transplant surgery in India, the different types of surgeries available, the success rates, and the cost involved. It will also address the risks and complications associated with the procedure. With this guide, you will have all the information you need to make an informed decision about whether a lung transplant is right for you and how to proceed with the procedure in India. Overview of Lung Transplant in India Lung transplantation is used to treat certain types of lung diseases, such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, bronchiectasis, cystic fibrosis, pulmonary arterial hypertension etc. These diseases can cause damage to the patient’s lungs, leading to shortness of breath, a decreased ability to exercise, and an increased risk of infection. In 1999, Dr. KM Cherian performed the first double-lung transplantation and the first combined heart–lung transplantation in India. This marked the beginning of the era of Lung transplantation in India. However the initial enthusiasm soon lost steam, until 2011 when another single lung transplant was done in Chennai. India has seen a tremendous growth in the numbers of lung transplants 2017 onwards with more and more centres taking up this challenge. A report published in Lancet Global Health suggests that the burden of chronic respiratory disease in India accounts for 32% of the global burden. Clearly these numbers indicate an unmet need for more trained transplant professionals and transplant centres across India. Thankfully many new transplant centres are coming up and India is slowly but surely coming of age as regards lung transplant. For people with advanced lung diseases termed as “End Stage Lung Disease”, lung transplantation may be the only option for a long-term cure. Lung transplant surgery is a life-saving procedure that can significantly improve quality of life for patients as well as their longevity. However, it is a complex procedure that carries certain risks. Therefore, it is essential to be fully informed about the procedure and its associated risks before making a decision about whether to proceed with Lung Transplant Surgery in India. For all general information related to lung transplant, you can watch this video in Hindi: Types of Lung Transplant Surgery There are broadly four types of transplant surgeries that may be used to treat end stage lung diseases: The type of Lung Transplant Surgery in India is determined by the extent of damage to the patient’s lungs, underlying etiology, availability of donor lungs and patient profile. Both single and double lung transplants have been performed for common indications including chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and primary pulmonary hypertension. Lung transplant operations, unlike other solid organ transplants, are somewhat unique in the fact that the donor block may be utilized for one recipient for a bilateral transplant or split to potentially benefit two patients with a single lung transplant each. Single-lung transplant: In this surgery, the diseased lung is removed and replaced with a healthy lung from another donor (cadaveric). The better out of the two lungs of the recipient is preserved.  The donor lung is connected to the patient’s pulmonary veins and arteries to provide blood flow to the new lung and to the bronchus (airway). This surgery can be done on ECMO/heart-lung machine or off-pump. Double-lung transplant: This is the most common form of lung transplantation worldwide as well as in India. In this surgery a pair of donor lungs are required from a brain-dead donor. The diseased patient’s lungs are removed one after the other and the healthy donor lungs are sequentially connected to the patient’s pulmonary blood vessels and bronchus. Double Lung transplant is the only acceptable transplant modality in patients with septic lung disease like cystic fibrosis or bronchiectasis for obvious concerns about contaminating the new lung with preexisting infection. This surgery can also be done on ECMO/heart-lung machine or off-pump. Living Donor Lobar Lung Transplant: In living lobar lung transplantation, two healthy donors are selected—one to undergo removal of the right lower lobe and the other to undergo removal of the left lower lobe. These lobes are then implanted in the recipient in place of whole right and left lungs. Heart Lung Transplant: A heart-lung transplant is a major operation to replace a person’s diseased heart and lungs with those from a donor. It’s offered to people with both heart and lung failure when all other treatment options have failed. This surgery is done on a heart-lung bypass machine. The donated heart and lungs will be put en-bloc in place and connected to the surrounding blood vessels and the windpipe (trachea) Indications for Lung Transplant Surgery in India Most candidates for lung transplant surgery will have been diagnosed with an End Stage Lung Disease. These are the common diagnosis for which lung transplantation is done: Eligibility Criteria for Lung Transplant Patients need to meet a broad range of criteria to be eligible for Lung Transplant Surgery in India. They must: Pre-operative Preparation for Lung Transplant Surgery Preparation for lung transplant surgery includes both medical and psychological aspects. Medical: The medical team will assess your overall health to determine whether you are a good candidate for surgery. This is called “Lung Transplant Evaluation”. Based on the assessment you will be ‘listed’ for a lung transplant with the national and regional organ regulatory bodies (ROTTO, SOTTO, NOTTO) , if found fit. They will then monitor your progress while you are on the waiting list to see if you continue to meet the

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Kamran Ali

Best Lung Cancer Surgeon in Delhi: Learn All About Lung Cancer

Lung cancer is one of the most common cancers and it affects millions of people in India every year. It is one of the leading causes of cancer-related deaths. The number of cases have also been on the rise, including in non-smoker population. 1 in 16 people will be diagnosed with Lung cancer in their lifetime. The rising incidence and delayed diagnosis of lung cancer in India are grave concerns. For those who are suffering from this condition, finding the best lung cancer surgeon in Delhi is crucial in order to get the best treatment. In this article we will try to present all the important information about lung cancer and its treatment, including surgery and other options. We will also try to highlight the important factors to keep in mind while choosing your treating physician. Introduction to Lung Cancer Abnormal and uncontrolled growth of cells in the lung tissue can lead to formation of lung cancer. The cancer that originates in the cells of the lung is called a “Primary Lung Cancer” and if the cancer cells reach the lung from some other organ, it is called a “Secondary Lung Cancer“ Broadly, Primary lung cancers are classified into 2 main types, based on the cell of origin: NSCLC is the most common type of lung cancer, accounting for approximately 80 – 85% of all cases. The three main varieties of NSCLC are: SCLC occurs in about 15-20 people out of 100, mostly in smokers. It is a type of Neuroendocrine tumour (NET). It is characterised by a rapid spread of tumour in the body. Lung cancer is the 2nd most common cancer in the world (most common in men, 2nd most common in women), according to Global Cancer Observatory (World Health Organization). Read more about Lung cancer statistics here. It is also one of the leading causes of cancer-related deaths in India. Lung cancer kills almost 3 times as many women as Breast cancer, and almost 3 times as many men as Prostate cancer Smoking is the most common risk factor for lung cancer. Other risk factors for lung cancer include second-hand smoke, exposure to certain chemicals, air pollution, radon gas and asbestos exposure, genetic predisposition, underlying lung disorders like COPD, arsenic in drinking water and increasing age. Symptoms of Lung Cancer The symptoms of lung cancer vary depending on the type and stage of the disease. Early signs of lung cancer may include: Read more about: Symptoms of Lung Cancer Lung Cancer Signs & Symptoms Causes of Lung Cancer Smoking is the number one cause for development of lung cancer. Cigarette smoke contains thousands of dangerous chemicals, out of which about 70 are cancer causing agents. Cigarette smoke is responsible for about 80% to 90% of all lung cancer cases in India. There is also a lot of Bidi and Hukka smoking in India as well. Second-hand smoke: Adults who are exposed to second hand smoke have a 20-30% risk of developing lung tumours. Other risk factors for lung cancer include exposure to certain chemicals, air pollution, asbestos exposure, increasing age, family history, previous lung diseases like COPD, exposure to Radon gas, arsenic in drinking water etc. Diagnosis of Lung Cancer The diagnosis of lung cancer requires a detailed history and a complete physical examination in the clinic. If your doctor suspects lung cancer you will be asked to undergo a battery of investigations. These may include: Treatment Options for Lung Cancer The type and stage of lung cancer decides the treatment. The options available are: Surgery for Lung Cancer Surgery is the first-line choice for early stage lung cancer which means when the tumour has not yet spread beyond the lungs. When done timely surgery has the potential to cure the patient completely. But unfortunately very few lung cancers that present to doctors are operable due to delayed diagnosis. Since it is a complicated surgery you should opt for the best lung cancer surgeon in Delhi or your city. Radiation therapy Radiation therapy uses high-energy X-rays or other particles to kill cancer cells and shrink tumours. Chemotherapy It is a form of treatment that is used to kill cancer cells. Anti-cancer medications are administered in the vein, and the session lasts up to a few hours. The treatment is performed in cycles of 1-3 weeks. It can be given pre-surgery, post-surgery or even as definitive treatment alone or with radiation therapy. Targeted therapy It is a type of treatment that uses drugs to target specific cancer cells. So your doctor may recommend molecular targeted therapy that includes the administration of drugs that work in subsets of patients whose tumours have specific genetic changes that have the potential of promoting tumour growth. Proton therapy Proton therapy is a type of radiation therapy that uses protons instead of X-rays to treat cancer. It can be used to treat lung cancer, but it’s relatively new, and not all centers have the capability to provide it. Immunotherapy Immunotherapy is a type of treatment that helps the body’s immune system to fight cancer. It can be used alone or in combination with other treatments. Checkpoint inhibitors: These drugs block certain proteins on the cancer cells that help them evade the immune system.CAR T-cell therapy: This is a type of immunotherapy that involves removing T cells from the patient’s blood, altering them in a lab to recognize and attack cancer cells, and then infusing them back into the patient. Supportive Care Supportive care is an essential part of lung cancer treatment. It includes measures to control symptoms, improve quality of life, and prevent complications. It can include: Finding the Best Lung Cancer Surgeon in Delhi This can be a daunting task because there are many surgeons in the city. So it can be difficult choice to make. To find the right or best lung cancer surgeon in Delhi or your nearby city is to do some research and ask for referrals from your doctor or other healthcare professionals. Once you have zeroed

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Surgery for empyema thoracis
Kamran Ali

Empyema Surgery in Delhi: Decortication

Empyema Surgery in Delhi is now very easily possible. Empyema thoracis is a serious medical condition in which pus accumulates in the pleural space of the lungs. It is a life-threatening condition that can be caused by a bacterial infection, tuberculosis, a foreign body in the chest, or a complication of another medical condition. The underlying cause of empyema must be identified and managed before proceeding with any treatment. Surgery is often recommended to remove the infected pus and to restore normal lung function. This type of surgery can be a complex and lengthy procedure that requires the expertise of a thoracic surgeon. In this article, we will discuss what is empyema and how surgery can help treat it. We will review the different types of surgeries available and explain how a thoracic surgeon can help you manage your condition. What is Empyema Thoracis? Empyema is a medical condition in which pus collects in the pleural space of the lungs. An empyema is classified as a suppurative lung infection. Suppuration is the formation of pus. Because it is a serious condition so it requires prompt diagnosis and treatment since it can be fatal. The pleural space is the area outside the lungs where the pleural membranes (lung membranes) surround the lungs. The pleural membrane is a thin sheet of tissue that covers the inside of the chest wall and the outside of the lungs. It is made up of two layers – the parietal layer and the visceral layer. The visceral layer lines the outer surface of the lung and the parietal layer lines the chest wall. The pleural space is normally filled with a small amount of a clear, thin fluid that lubricates the inside of the chest, allowing the lungs to move back and forth during breathing. Often patients need surgery for empyema thoracis if they cannot be managed conservatively. Causes of Empyema It can result from a variety of bacterial infections that spread from the chest into the pleural space. Pleural empyema can result from an existing lung infection, such as tuberculosis or bacterial pneumonia. It can also occur after a lung infection that has been treated with antibiotics. This can occur if the infection is not completely eradicated or if the antibiotics are not effective against the infecting bacteria. Other common reasons are: Stages of Empyema and Stage-wise Treatment of Empyema in Delhi The evolution of Empyema goes through three stages. First Stage: The first is the presence of free-flowing fluid (effusion) which usually resolves with antibiotics and non-invasive treatment. If it is left untreated the effusion becomes complicated. Second Stage: In this there is a deposition of fibrin and membranes which leads to formation of septations or loculations in the fluid leading to comparmentalization of the fluid into different pockets. Both antibiotics as well as some form of pleural drainage is required in this stage. Third Stage: If the loculated fluid is not drained the fluid will start organising (third stage) into thick pus and the fibroblasts will coalesce to form a thick pleural peel between the visceral and parietal pleura. This peel can ultimately encase the underlying lung and will prevent the lung from expanding. For an easy understanding the collapsed underlying lung can be compared to an orange and the thickened pleural peel around the lung to the peel of the fruit. This stage requires Surgery for Empyema Thoracis because the lung is usually trapped and unable to expand. Symptoms & Signs The symptoms of empyema vary depending on the underlying cause and the extent of the infection. Most patients experience symptoms similar to pneumonia, including fever, chills, cough, chest pain, and difficulty breathing. Other symptoms of may include chest pain behind the breastbone, pleuritic pain (pain that worsens when taking a deep breath), and low oxygen levels in the blood. As the infection spreads, patients may experience sweating, high fevers, and general weakness. Patients who may be experiencing symptoms of empyema should consult a health care professional so as to determine the cause of their symptoms. A health care professional can perform a physical examination, take a medical history, and order diagnostic tests like a Chest X ray, CT scan and analysis of the pleural fluid/pus. If Pleural Empyema is diagnosed, it may need surgery. Surgery for Empyema in Delhi In many cases, empyema thoracis requires surgical treatment. A thoracic surgeon will examine the patient to identify the extent of the infection and the location of the pus. They will review the patient’s medical history and current medications to determine the best treatment plan. The surgery for empyema thoracis is called “Drainage and Decortication” The goals of this surgery are: Traditionally the approach used for empyema surgery is an open approach called a “Thoracotomy”, which is a large cut on the side of the chest and involves cutting the muscles and spreading the ribs. This allows the surgeon to put his hands inside the chest to operate. Decortication Surgery for Empyema in Delhi Dr. Kamran Ali does most of his Empyema operations by a minimally invasive technique called Video Assisted Thoracoscopic Surgery (VATS). This technique involves making tiny key hole cuts on the side of the chest (1 to 3), without muscle cutting or rib spreading. With the help of a camera (thoracoscope) and double hinged long working instruments, the whole surgery can be completed by looking at a monitor. So all goals of an empyema surgery that can be achieved by an open surgery can be safely replicated by VATS. Uniportal VATS Drainage and decortication of empyema is a special type of VATS surgery, because it utilizes only a single 3-4cm incision to perform this surgery. Occasionally these surgeries may not be possible by VATS but would need a conventional open surgery approach especially when the pleura has calcified or in case of fibrothorax. Advantages of Surgery for Empyema (in Delhi) by VATS VATS decortication usually translates to lesser post operative pain, faster recovery and a shorter hospital stay. It

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Can you live with one lung
Kamran Ali

Can you live with one Lung?

  The answer is YES !!! You can live with one Lung Living a one-lunged life may sound scary but the good news is you can totally live with one lung. Not only that, you can actually thrive with just one lung. A normal life after pneumonectomy is a reality. Many diseases of the lungs may sometimes require a radical surgical treatment in the form of complete removal of one lung from a person’s body. This surgery is called a “Pneumonectomy”. So you will be living a life with just one lung after this surgery. Certain medical conditions or an injury to the lung may sometimes irreversibly damage the lung. It can lead to symptoms like repeated chest infections manifesting as fever, cough or/and shortness of breath. Often patients may present with frequent bouts of blood during coughing (hemoptysis). Common diseases that cause this clinical scenario are Tuberculosis, Bronchiectasis, Fungal lung diseases (Aspergilloma, Mucormycosis), Lung cancer, Lung abscess etc. Your doctor would first try to treat you conservatively with medicines. But often he or she may suggest a surgery for removal of the diseased lung. You will then be referred to a Thoracic Surgeon (Chest Surgeon) who will perform this surgery. The first response of a patient and their family on hearing about such a surgery is that; Is it even possible to live with only one lung? Isn’t it supposed to cut down a person’s breathing capacity into half?  People surviving with a single kidney is often heard of, but living with a single lung; that is rare. Patients often ask us whether the removed lung will re-grow, like in case of Liver? What will happen to the empty space in the chest after removal of lung ? Although it is not possible for the lung to re-grow but the body does compensate by slow and gradual expansion of the other remaining lung towards the void. Post pneumonectomy patients in due time reach about 70-80 percent of their pre surgery lung function. The heart also drifts towards the post pneumonectomy space. A fluid fills the residual space in the chest cavity which slowly gelatinizes into a proteinaceous material and the chest scaffold collapses slightly. This is how mother nature helps to obliterate the “empty space” left behind by removal of a lung. But before performing such a major surgery your surgeon will thoroughly evaluate you to decide whether you are fit or not. This mainly involves blood tests, radiological investigations and a complete cardio-pulmonary evaluation. Assessment of the pulmonary reserves especially in regards to a lung resection is the most vital. Tests like Pulmonary function test (PFT), Diffusing capacity for Carbon Monoxide (DLCO), Lung Perfusion scan and Cardio-pulmonary exercise testing (CPET) will help the surgeon to reach to a conclusion if a Pneumonectomy can be safely done or not. These days a Pneumonectomy can be performed by minimally invasive techniques like Video Assisted Thoracoscopic Surgery (VATS) or Robotic Surgery. The whole surgery can be done by tiny key-hole incisions on the chest. There would be no need for a big cut on the chest or cutting muscles or rib spreading. But the approach for surgery would be decided by your surgeon on a case to case basis. Once a patient has recovered from the surgery, they can live a pretty normal life. Living with one lung doesn’t usually affect everyday tasks or life expectancy, though a person with one lung wouldn’t be able to exercise as strenuously as a healthy person with two lungs. For instance climbing stairs may make such patients more short of breath as compared to normal people. However that also varies from patient to patient. People have run marathon with a single lung, for example this “one lung runner” https://www.google.co.in/amp/www.thebetterindia.com/74187/kanishka-lahiri-cancer-survivor-runs-half-marathons-climbs-mountains-trekking-one-lung-runner/amp/?client=ms-android-motorola&espv=1 Similarly 46 year old Dave has 1 lung. But it didn’t let it stop him from completing the Prudential RideLondon 100 mile cycle in 2016. https://www.blf.org.uk/your-stories/1-lung-1-life-100-miles Pope Francis also lost one of his lung to a childhood pneumonia. But he carries on his papal duties as efficiently as other cardinals. So it is definitely possible to live a normal life with a single lung provided the remaining lung is maintained in good health. One can do that by avoiding smoking and environmental pollution. Also by being up to date with Pneumonia and Influenza vaccines to guard against any serious lung infections. It is vital that if you or anyone you know needs removal of a lung, you should research well. You should get yourself treated only by a Surgeon with considerable experience in doing this complicated surgery. Feel free to get in touch with our team to discuss your case with Dr. Kamran Ali

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Best Thoracic Surgeon in Delhi
Kamran Ali

The Best Thoracic Surgeon in Delhi NCR

  Becoming a good Surgeon is a lifelong process. It is every young surgeon’s dream. In pursuit of becoming a “good” surgeon they put their blood and sweat into it. Imagine what it requires for being the “best” in your craft. To be called the best chest surgeon or thoracic surgeon in Delhi or any geographic domain, is an honour. But can everyone become the best? It’s not an easy question to answer. Especially if you look at it from a patients perspective.  When your primary physician or other specialist like a Pulmonologist tells you that you need to see a thoracic surgeon, it can feel unnerving. Finding a highly skilled thoracic surgeon can help put you at ease. But how do you find the best thoracic surgeon in Delhi or India for you or your loved ones?  Probably there are no specific measurable metrics which can define a good or best Surgeon. But may be if there were some, then they would be –  Knowledge, Degrees, Experience, Empathy, Manual dexterity, Leadership quality, Mental toughness, Ability to take critical decisions and handle complex surgeries etc. Unlikely that you or any one else can assess a surgeon on ‘all’ these indices. But here are some important factors to keep in mind in your pursuit of the best thoracic surgeon in Delhi or anywhere else: Dr. Kamran Ali –One of the best thoracic surgeon in Delhi Dr. Ali is a Lung Transplant and Thoracic (Chest) Surgeon who has trained extensively at Centres of Excellence across the World. He is passionate about Surgical treatment of End Stage Lung Diseases, Advanced Lung Failure, Infectious/Inflammatory Lung Diseases and Lung Cancer. He is proficient in handling the entire spectrum of thoracic (chest) surgery diseases. He graduated in Medicine from JNMCH, Aligarh, following which he finished his residency in Surgery from the prestigious Sir Ganga Ram Hospital, New Delhi. He then trained extensively in Thoracic Surgery in India, South Korea and Japan. His training in India at Medanta the Medicity, covered the entire spectrum of General Thoracic Surgery. At Seoul National University, South Korea he mainly focused on acquiring the skills of Minimally Invasive Thoracic Surgery (VATS and Robotics), while his time at National Cancer Centre and Tokyo University in Japan was spent mostly in learning complex lung resections for thoracic cancers. After the fellowships, he worked as a Consultant chest surgeon in Thoracic Surgery with the Fortis Group of Hospitals, Delhi NCR and later at Sir Ganga Ram Hospital, New Delhi. In 2020 he was selected for a Fellowship in Lung Transplant at The Medical University of Vienna, AKH, Austria, which is one of the highest volume Lung Transplant centres in the world. There he was actively involved in all aspects of lung transplantation including patient selection, surgical management (donor & recipient), as well as post operative care. He was also part of the surgical team which did Europe’s 1st and World’s 2nd Lung Transplant for COVID-19 ARDS. Before joining Max Superspeciality Hospital, Saket, New Delhi he was working as a Senior Consultant in Lung Transplant & Thoracic Surgery at Marengo QRG Hospital, Faridabad and Yashoda Hospitals, Hyderabad and successfully performed many complex Double and Single Lung Transplants. Dr. Ali is a respected figure in the Indian medical community and is often invited to speak at conferences and seminars on the topic of lung transplantation and thoracic surgery. He also has to his credit many scientific publications in international and national journals. He also serves as Associate Editor of Asia Thoracoscopic surgery Education Program (ATEP) Bulletin and Guest editor for Journal Of Visualized Surgery (JOVS), apart from being a reviewer for many international and national journals.  Apart from his surgical and academic expertise, he is very well known for his impeccable bedside manners. He is quite popular amongst his patients and puts them at ease right from the word go, and has great interpersonal communication skills. Dr. Ali’s passion for his work is reflected in the dedication and commitment he brings to each and every surgery he performs. He is known for his meticulous attention to detail and his willingness to go the extra mile to ensure the best outcomes for his patients. He is also an advocate of patient-centered care and works closely with his patients to provide them with the best possible care. For the above mentioned qualities, many of his patients refer to him as one of the best chest surgeon or thoracic surgeon in Delhi.

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